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Preliminary Toxicology

Here at Sequani, we are proud of the support we give to clients and the excellent way we manage early stage toxicology studies in rodent and non-rodent species.  At the early stages of product development rapid turnaround and communication of results are crucial. The Sequani team is second to none in providing this service with attention to detail and close collaboration with our Sponsors. We have extensive experience in this area including working with challenging molecules.

Introduction

A highly experienced team of study directors works closely with clients to ensure our work meets the needs of both product development and international regulatory standards.

We can conduct studies by all routes of exposure other than inhalation and we have extensive experience in undertaking studies by the dietary route.

In addition to the standard toxicology services, we are able to offer special expertise in the following areas:

  • Creative and responsive services for early stage investigative toxicology.
  • Non-rodent (dog and minipig) toxicology.
  • Toxicology studies in mice.
  • Toxicokinetic support.
  • Meeting challenging time-lines.
  • Highly experienced in-house toxicological pathologists.

Our study directors are highly responsive and are actively involved with their projects from inception through to report finalisation. They work closely with the on-site laboratory animal services, formulation sciences, analytical chemistry, bioanalysis, clinical pathology, biomarkers, pathology, QA and information technology staff to ensure that clients receive high quality studies and reports, whatever the type.

We have a reputation for meeting, or beating, reporting dates even against the most difficult target times. We always provide good practical scientific input into the study design and reporting but also have the ability to contribute a more specialised scientific content where required.

Study Types

  • • Comparative and early development toxicity
    • Rodent and non-rodent
    • Standard screening designs available
    • Bespoke studies
  • Toxicokinetics
  • MTD and dose range-finding
  • Repeat Dose Toxicity
  • Investigative studies
    • Bespoke study designs to investigate specific toxicological issues

Dosing Routes

  • Oral gavage
  • Oral dietary
  • Oral capsule
  • Dermal

Species

  • Rat
  • Mouse
  • Rabbit
  • Dog
  • Minipig
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