+ Phase-II-support-Genotoxicology

Genetic toxicology

A comprehensive range of genetic toxicity services for preclinical assessment and the early screening of candidate compounds. The Genetic Toxicology team works in a purpose-built suite of laboratories and offers a comprehensive selection of genetic toxicity studies.

Introduction

This includes the complete standard range of tests for preclinical safety assessment.  We also have links with other facilities for the placement of alternative investigative studies, where this is required to elucidate effects seen in earlier studies. and a range of studies suitable for the early screening of 

Study Types

  • Bacterial Reverse Mutation Test (Ames Test)
  • Gene Mutation in Mammalian Cells
    • L5178Y TK± (Mouse Lymphoma Assay) in microwell plates
  • Chromosome aberration
    • Human lymphocytes (HL)
  • In Vitro Micronucleus
    • Human lymphocytes
  • Rodent Micronucleus test
    • Mouse peripheral blood and bone marrow
    • Rat peripheral blood and bone marrow
    • Combination with repeat-dose toxicity
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