+ Question and Answers

Question and Answers

Before any new product can be put on the market, regulators need to be confident that any risk it presents is acceptable to humans, animals and the environment. 

By lawanimals cannot be used if working alternatives exist.

New Approach Methodology (NAMs)

NAMs seek to replace all current forms of animal and nonanimal testing. However, by law, animals cannot be used if working alternatives exist.

NAMs are faster, more reliable and cheaper than using animals

The UK is home to the world’s foremost centre for developing animal alternatives. It has a project to replace animals like dogs in regulatory testing by making NAMs fit-for-this purpose, which they currently are not. The project runs until 2025 and is at the proof-of-concept phase.

Sequani should switch to NAMs

Sequani, like all contract research organisations, already uses non animal methods either alongside animals or instead of them if they work.

Sequani uses Beagle Dogs

Dogs are mainly used to show that lifesaving new medicines, including those recently in the media for cancer and Alzheimer’s, are safe enough to advance to human testing. Dogs are not used to test industrial chemicals or in experiments with severe suffering.

Testing involving Animals is not relevant to humans

The most authoritative study on animal to human translation is thought to be from the IQ Consortium, and shows that rats, mice, rabbits, and dogs’ ability to predict human safety (NPV) is high:

Predict Human Safety


Median positive predictive value (PPV)

Median negative predictive value (NPV)













Sequani conduct toxicity tests on pregnant animals

The UK’s greatest drug scandal, mutations caused by thalidomide, occurred because tests were not undertaken on pregnant animals. When medicines or products say that they are not suitable for pregnant women it is because they can cause damage to a foetus while leaving the mother unaffected. 

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What we do


Drug Development
Getting a drug to market is an expensive and lengthy process. Our renowned flexibility, depth of experience and creative approach to non clinical strategy is the crucial support you need.


Crop Protection
We deliver outstanding scientific and technical expertise to support you through the safety evaluation phases of registration and re-registration projects for agricultural chemicals and other crop protection technologies.


Chemical Safety
Our team of highly skilled scientists and toxicologists provide expert toxicology services designed to meet the requirements of the REACH regulations and other international chemical registration schemes.